Kirby Griffis faced a rough playing field as counsel for Novartis Corp. in serial litigation over a cancer-fighting drug alleged to cause the death of bone tissue in the jaw. Novartis had already lost two cases in Florida, and he was set to go to trial before a judge whose rulings suggested she thought this third case would go the same way.

He faced an undeniably sympathetic plaintiff — a 67-year-old woman in a wheelchair who beat late-stage breast cancer that had metastasized to her bones. Novartis’ Zometa saved her life, only to cause osteonecrosis — bone death, which leaves sufferers in constant pain and sometimes facially disfigured. While Griffis had terrific scientists as his expert witnesses, some were terrible public speakers.

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