In a 20-page order issued Wednesday evening, U.S. District Judge Susan Illston of the Northern District of California rejected a patent asserted by Sequenom Inc., agreeing with a rival that the patent combined the discovery of a non-patentable law of nature and conventional scientific methods.

“The only inventive concept contained in the patent is the discovery of cffDNA, which is not patentable,” Illston wrote, referring to the use of cell-free fetal DNA in maternal blood as a way to screen for genetic disorders in place of riskier procedures like amniocentesis.

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