Johnson & Johnson was hit with a record $110 million verdict Thursday in the fifth trial over the safety of its talcum powder.

After more than a day in deliberations, a jury in Missouri state court came back with the verdict, which includes $105 million in punitive damages against Johnson & Johnson and $50,000 against talc supplier Imerys Talc America Inc., according to video coverage provided by Courtroom View Network.

The defeat breaks a winning streak for Johnson & Johnson, which won its first talc trial earlier this year and, on Tuesday, scored a defense verdict in the first bellwether trial over blood thinner Xarelto. The verdict also surpasses the sums awarded by other Missouri juries, who last year came out with verdicts of $55 million, $70 million and $72 million.