Mayer Brown has lost at least 15 partners since August, including the co-head of its global restructuring, bankruptcy and insolvency group, as the firm prepares to report a double-digit percentage drop in 2008 profits.

Significant partners have been leaving the Chicago firm since 2007, when new management took the helm. But the recent departures come as the firm ended merger talks with now defunct Heller Ehrman and laid off 33 U.S. lawyers.

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