For the past two weeks, the U.S. Justice Department has clashed with Anthem Inc. in a blockbuster antitrust trial rife with conflict. The government is fighting to block a $48 billion health care merger that Anthem’s tie-up partner—Cigna Corp.— appears to no longer want.

The drama of that trial, where Cigna’s chief executive hardly hid the strain between the insurer and its suitor, isn’t expected to be mirrored when Aetna Inc., on Monday, begins to defend its $37 billion takeover of rival Humana Inc.

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