Jacquelyn Kasulis, known for leading the high-profile prosecutions of Martin Shkreli and the Genovese crime family, has been tapped to head the criminal division of the U.S. Attorney's Office in Brooklyn.

U.S. Attorney Richard P. Donoghue of the Eastern District told staff in a memo Friday that Kasulis, a 2003 graduate of Columbia Law School and a former litigation associate at Kirkland & Ellis, would take over permanently as chief of the criminal division after serving in an acting capacity for three months.

She takes over for former division head Seth DuCharme, who joined U.S. Attorney General William Barr's staff in March.

In a statement provided to the New York Law Journal, Kasulis said she was “honored” to be selected for the role and to “continue my predecessors' efforts to support the excellent work of our prosecutors in their pursuit of justice.”

“I would also like to thank U.S. Attorney Richard P. Donoghue for this opportunity,” she said.

According to the memo, Kasulis joined the U.S. Attorney's Office in 2008, and has served in the general crimes, organized crime and business and business and securities fraud sections. She has also served as chief deputy in the general crimes section, and in 2017 was appointed to lead the business and securities fraud section.

During her tenure, Kasulis earned a reputation for white-collar criminal prosecutions, including in the six-week trial in 2017 of pharmaceutical executive Shkreli, who was charged and convicted of four interrelated fraud schemes that resulted in $20 million in losses to investors.

Kasulis also led the office's prosecution of two former Goldman Sachs bankers and a wealthy Malaysian financier for their role in a $2.7 billion money laundering and bribery conspiracy related to Malaysia's investment development fund, 1Malaysia Development Berhad.

Her other major cases included the prosecutions of an investment fund manager for defrauding 75 investors in a $17 million Ponzi scheme in Long Island and of two HSBC foreign exchange cash trading executives charged with misusing funds from a client who HSBC hired to execute a $3.5 billion foreign exchange transaction.

While working in organized crime, Kasulis won the Federal Law Enforcement Foundation and Federal Executive Board awards for leading the prosecution of more than 15 Genovese crime family members and associates, which included the conviction of three presidents of the International Longshoremen's Association for their involvement in a 30-year extortion scheme.

In 2013, she also led the trial team that convicted Gambino crime family associate John Burke of racketeering and murder.