A new presidential administration necessarily ushers in a change in leadership and presents the possibility of a different antitrust regime. Yet these new appointees must still grapple with the vestiges of the old guard. The administration of newly elected President Joe Biden has inherited large, ongoing antitrust investigations along with mounting bi-partisan pressures to consider sweeping changes to antitrust law. Though both President Biden and Vice President Kamala Harris have voiced their support for stricter antitrust measures, they have not concretely defined their antitrust priorities since taking office. They also have not yet nominated individuals to key leadership positions in the Antitrust Division of the Department of Justice (DOJ) or the Federal Trade Commission (FTC). As the Biden administration sets its antitrust policy agenda, will their choices have a transformative effect on antitrust policy—or just continue the status quo?