The Delta variant is wreaking havoc on return-to-work initiatives. Nevertheless, employers inevitably will require most employees to return to office, whether or not with hybrid schedules, and will require that they be vaccinated. This may happen in fits and starts, and not always with the willing participation of employees, many of whom enjoy working from home, or may be unable to be vaccinated. Lawyers representing management therefore need to understand how best to advise clients on how to respond to requests from employees to be exempted from these policies.