Amgen Inc. has won a patent infringement verdict worth $10 billion.

No damages were in play in Immunex v. Sandoz, but Amgen’s market cap popped $10 billion Monday on news that it successfully defended two patents on its rheumatoid arthritis biopharmaceutical Enbrel.

Following a two-week bench trial last fall, U.S. District Judge Claire Cecchi of the District of New Jersey entered a permanent injunction against Sandoz Inc., which has been gunning for Enbrel’s validity since 2013. Amgen rings up nearly $5 billion a year in domestic sales of Enbrel—about 20% of its U.S. revenues—and the patents still have nearly a decade to run.

So Cecchi’s 85-page opinion Thursday rejecting a host of Sandoz validity challenges was big enough to make Amgen the Stock of the Day for Investor Business Daily the following Tuesday.

It’s a huge win for Amgen’s trial team, which was headed up by San Francisco/Silicon Valley Sidley Austin partner Vernon Winters and one of the firm’s Chicago partners David Pritikin. It also included Washington, D.C., partner Jeffrey Kushan and local counsel from Walsh Pizzi O’Reilly Falanga.

Amgen CEO Robert Bradway said in a written statement that the company was pleased with the outcome. “Protecting intellectual property is critical to incentivize innovation and the large investments in research and development” needed to fully develop new medicines, he said.

Sandoz, represented by Winston & Strawn, Williams & Connolly and Gibbons, vowed to appeal to the Federal Circuit and said the parties have agreed to expedite it.

“Valid intellectual property should be respected, however, we continue to consider the patents in this case to be invalid,” said Carol Lynch, president of Sandoz US, in a written statement.

Enbrel is the first FDA-approved fusion protein, according to Cecchi’s opinion. The protein is made by combining the extracellular region of a 75 kilodalton Human Tumor Necrosis Factor receptor, known by the shorthand p75 TNFR, with a portion of IgG1 immunoglobulin. Hoffmann-La Roche filed the original applications in the 1990s but eventually licensed the invention to Amgen and its subsidiary Immunex Corp., and the FDA approved Enbrel in 1998. U.S. Patent 8,063,182, on the protein, and No. 8,063,522, on the method of manufacture, issued in 2011 and 2012 respectively.

Sandoz, which is the generic and biosimilar division of Novartis, launched its initial attack in the Northern District of California in 2013. U.S. District Judge Maxine Chesney of the Northern District of California ruled, and the Federal Circuit agreed, that it was premature, because Sandoz hadn’t yet applied for FDA approval of its competing biosimilar drug, which it calls Erelzi.

In the meantime, Kyle Bass’ Coalition for Affordable Drugs and Coherus BioSciences Inc. brought administrative validity challenges at the USPTO, but the agency declined to institute proceedings in either case.

As Sandoz closed in on FDA approval in 2016, Amgen, Immunex and Roche brought the present suit in New Jersey. Sandoz conceded infringement but argued that Amgen’s patents are invalid for written description, enablement, obviousness and obviousness-type double patenting.

Cecchi found the patents provided plenty of information that would lead a person of skill in the art to the active ingredient in Enbrel. The claim specification refers to a 1990 research article, which in turn notes that the entire nucleotide sequence of the p75 TNFR had been deposited with the National Institute of Health’s genetic sequence database.

“Because the p75 TNFR sequence and the IgG1 sequence were well known and accessible to a POSA, a reproduction of the known sequences was not required to be explicitly included in the Patents-in-Suit in order to claim a novel combination of those sequences,” Cecchi wrote.

As for obviousness, Cecchi found that Enbrel was met with praise and commercial success and that it satisfied a long-felt need. Amgen also argued that Sandoz’s copying of Enbrel pointed to non-obviousness, but Cecchi ruled that because biosimilars have to be almost identical to obtain FDA approval, copying could not be held against it.

But regardless of how that factor played out, she noted, “such finding would not have any material impact on the outcome of the Court’s obviousness analysis.”