Article 1, Paragraph 8, Clause 3 of the U.S. Constitution, the Dormant Commerce Clause, has for years been considered an arcane doctrine of American constitutional law; however, recent cases brought by out-of-state cannabis applicants have challenged its constitutionality as it pertains to state cannabis licensing residency requirements. This article takes a look at the issues underpinning two recent lawsuits brought against Missouri and Maine by non-resident applicants seeking cannabis licensure in states with durational residency requirements, and explores the potential impact on the emerging regulatory framework and adult use market being established in New Jersey.