President Joe Biden's executive order requiring vaccines for employers who employ over 100 people, and the anticipated rules from the Occupational Safety and Health Administration (OSHA) regarding this issue, will likely meet the same resistance in the courts as private vaccine mandates have. Further, employers with less than 100 employees are increasingly requiring vaccines. States, municipalities and health care organizations all over the country have instituted vaccine mandates. Legal challenges are inevitable, and, in many instances, underway. The Equal Employment Opportunity Commission (EEOC) provides some guidance on instituting these mandates, and courts are starting to weigh in with decisions supporting vaccine mandates.