Per- and poly-fluoralkyl substances (PFAS), known as "forever chemicals" due to their persistence in the environment, have been manufactured and used in a variety of industries for nearly 80 years. Following decades of concerns with human health effects and environmental contamination, the U.S. Environmental Protection Agency (EPA) laid out its PFAS Strategic Roadmap: EPA's Commitments to Action 2021-2024 (PFAS Roadmap) and emphasized the need to ensure science-based decision-making. See PFAS Strategic Roadmap: EPA's Commitments to Action, 2021-2024, at 7 (October 2021) //www.epa.gov/system/files/documents/2021-10/pfas-roadmap_final-508.pdf. As the EPA notes: "Regulatory development, either at the state or federal level, would greatly benefit from a deeper scientific understanding of the exposure pathways, toxicities, and potential health impact of less-studied PFAS." The most researched of the tens of thousands of PFAS are PFOA and PFOS, so the EPA's initial regulatory efforts focused on those two compounds. But, as described below, the regulations developed under the EPA's PFAS Roadmap go beyond PFOA and PFOS, inviting scrutiny by the public, regulated entities, and various stakeholders.