Last month, the U.S. Environmental Protection Agency (EPA) released for public comment its Interim Framework for Advancing Consideration of Cumulative Impacts. The Framework encourages EPA programs to consider the totality of exposures to chemical and nonchemical stressors affecting human health and the environment, together with vulnerabilities and susceptibilities that may increase the likelihood that exposures will result in illness or other injuries. By engaging with communities and considering the cumulative effects of an action on the exposed population, the EPA can best protect citizens from environmental injuries.