Eli Lilly & Co. will pay a combined $1.42 billion, including the largest criminal fine in history — $515 million — to settle charges that it illegally marketed the anti-psychotic drug Zyprexa for off-label use, federal prosecutors announced Thursday.

Zyprexa was approved by the Food and Drug Administration only as a treatment for schizophrenia and bipolar disorder, prosecutors said, but Lilly allegedly set out to market the drug to elderly patients as a treatment for dementia, Alzheimer’s, agitation, depression and generalized sleep disorder.

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