A Boston federal judge has imposed a $321.6 million criminal fine against Merck & Co. Inc. for its Vioxx promotion and marketing activities, bringing the company’s payout in recent months to nearly $1 billion for illegal marketing.

On April 19, U.S. District Judge Patti Saris of the District of Massachusetts imposed the fine against Merck’s U.S. unit following its December 2011 guilty plea. Merck violated the Food, Drug and Cosmetic Act by introducing a misbranded drug into interstate commerce.

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