The U.S. Court of Appeals for the Federal Circuit has upheld the Patent Trial and Appeal Board’s invalidation of next-generation DNA sequencing patents that Columbia University is asserting against Illumina Inc.

Columbia says technology its researchers developed is driving “blockbuster commercial success” at San Diego-based Illumina, but the Federal Circuit agreed with the PTAB that the three patents at issue were obvious or anticipated based on older patents and scientific research dating back to the 1980s.

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