Drug prices. What two other words generate more public passion, political interest and regulatory heartburn in the pharmaceutical industry?

All those things were on display in July 2014 when Gilead Sciences Inc. received a letter from U.S. Senators Ron Wyden, D-Ore., and Chuck Grassley, R-Iowa, wanting to know why the company’s blockbuster Hepatitis C drug, Sovaldi, was priced at $1,000 a pill in the United States. The senators warned publicly that the price tag could cost Medicare and Medicaid billions more annually, even as the drug was being sold much more cheaply in other countries.

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